New insights into the prevention and treatment strategies for hypertrophic scars and keloids
نویسندگان
چکیده مقاله:
Hypertrophic scars and keloids are fibrosis abnormalities associated with the accumulation of collagen and extra cellular matrix components. These scars are caused by abnormal wound healing, which may occur after skin injuries caused by surgery, trauma, burns, etc. and may have a large impact on the patients’ quality of life. Hypertrophic scars and colloids in addition to aesthetic problems can cause functional disruption due to tissue contraction and itching. Large numbers of research are currently being performed in the area of scar prevention or treatment, but since the physiopathological mechanisms of scar formation have not been fully elucidated, the current strategies are still unsatisfactory. In this review, we discuss the recent biological advances in scar formation and current and future strategies for the prevention and treatment of hypertrophic and keloid scars.
منابع مشابه
Hypertrophic scars and Keloids
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the ...
متن کاملHypertrophic scars and Keloids
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the ...
متن کاملTreatment of keloids and hypertrophic scars.
Clinicians always find it difficult to treat hypertrophic scars and keloids. Various treatment modalities are available. Intralesional corticosteroids, topical applications, cryotherapy, surgery, laser therapy, and silicone sheeting are the widely used options. Radiation therapy can also help in cases of recalcitrant keloids. Most recently, pulsed-dye laser has been successfully used to treat k...
متن کاملThe most current algorithms for the treatment and prevention of hypertrophic scars and keloids.
BACKGROUND Previous reports on the treatment of hypertrophic scars and keloids have not described clear algorithms for multimodal therapies. This article presents an evidence-based review of previous articles and proposes algorithms for the treatment and prevention of hypertrophic scars and keloids. METHODS The methodologic quality of the clinical trials was evaluated, and the baseline charac...
متن کاملInsights into the Pathophysiology of Hypertrophic Scars and Keloids: How Do They Differ?
GENERAL PURPOSE To provide information about the clinical presentation of hypertrophic scars and keloids based on their varied structural components. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After completing this continuing educati...
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عنوان ژورنال
دوره 10 شماره 4
صفحات 271- 284
تاریخ انتشار 2020-01
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